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VITAMIN B1+B6

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vitamina-b1-+-b6
  • Active substances: Vitamin B1, Vitamin B6
  • Recommended solution in state of vitamin B hypovitaminosis, convalescence, malabsorption, poisoning, liver failure, nervous system disorders, paresis, rheumatic conditions, poisoning and skin problems.
  • Target species: horses, cattle, sheep, goats, swine, dogs
  • Administration: subcutaneous or intramuscularly
  • Packing:  20 ml

 

COMPOZITION

1 ml of product contains:

Thiamine hydrochloride (Vitamin B1)…………….. 30 mg

Pyridoxine hydrochloride (vitamin B6)……………. 20 mg

Excipients: Sodium chloride, sodium metabisulfite, water for injections ad…………………………………………………1 ml

 

PHARMACOTHERAPEUTIC ACTION

Vitamins B1 and B6 are two of the vitamins of the vitamin B complex, with deep implications for metabolism.

Vitamin B1 (thiamine hydrochloride) is involved in carbohydrate metabolism (decarboxylation of pyruvic acid). Deficiencies in vitamin B1 determines accumulation of pyruvic acid in the tissues, causing nervous system disorders (polyneuritis, paresis, paralysis, contractures). Vitamin B1 has a major role in the transformation of carbohydrates into fat deposit and proteolytic processes in the body.

Vitamin B6 (pyridoxine hydrochloride) actively participates in the metabolism of amino acids (especially tryptophan), and fat metabolism, favoring their synthesis.

Both vitamins act synergistically in preventing and combating nervous diseases (neuritis, polyneuritis, paralysis) in myopathy, myalgia, gastrointestinal atonia, edema of cardiac origin acetonaemia.

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TARGET SPECIES

Horses, cattle, sheep, goats, swine, dogs.

 

INDICATIONS

In horses, cattle, sheep, goats, swine, dogs in:

- The state of hypovitaminosis B, convalescence, malabsorption, poisoning, liver failure

- Nervous system disorders: neuritis, polyneuritis, paresis, paralysis

- Prestomacelor paralysis, rheumatic conditions, myopathy, myalgia

- Poisoning, acetonaemia, dermatitis, edema of cardiac origin, allergies

 

DOSAGE, ROUTE AND METHOD OF ADMINISTRATION

Product should be administered by the subcutaneous route or intramuscular injection in the following doses:

- Horses and cattle – Adults: 5-10 ml / day

Youth: 2-5 ml / day;

- Sheep, goats, swine – Adult: 2-5 ml / day

Youth: 1-2 ml / day

- Dogs: 1-2 ml / day.

Duration of treatment is 3-4 days or until symptoms disappear.

 

CONTRAINDICATIONS, PRECAUTIONS AND ADVERSE REACTIONS

Big doses administered over a long period can cause allergic phenomena, nervousness, dizziness, upset stomach, vomiting, peripheral vasodilatation and impaired breathing. In such cases, discontinue administration of the product. No special precautions needed for the use of vitamins B1 and B6 during pregnancy and lactation.

High doses of Vitamin B1 + B6 may interfere with the metabolism of other vitamins of group B.

Due to its dopacarboxilazis activation in peripheral tissues of the brain, pyridoxine reduces or removes the antiparkinsonian action of levodopa.

Pyridoxine increases the elimination of nitrofurantoin almost at double level.

Pyridoxine may influence calcium pantothenate stability because stability has a different pH. Avoid this combination.

Vitamin B1 is synergistic with vitamin C; vitamin B1 administration reduces requirements of vitamin C.

For thiamine hydrochloride and pyridoxine hydrochloride administration it was found that the lethal effects occur at doses of at least 1000 times higher (intravenously) to the RDA.

Thiamine hydrochloride is incompatible with oxidizing agents, reducing iodides, carbonates, acetates, sodium phosphate, borax, mercury chloride. Form precipitates with iodine, tannic acid, ammonium iron citrate. Is degraded by riboflavin, penicillin, copper ions.

It is incompatible with alkaline solutions (sodium phenobarbital, sulfonamides sodium, sodium citrate, sodium hydrogencarbonate, trometamol) with basic alkaloids soluble, with solutions of sugars (glucose, lactose), alcohol, gelatin. Glycerol concentration above 70% can cause degradation of thiamine. It is incompatible with acids and acid salts except benzoic acid and salicylic acid.

Cyanocobalamin breaks proportional to the concentration of vitamin B1 only light. Degradation of the environment increases the pH, deviates from the limits of 4.5 to 6.5. Pyridoxine hydrochloride is incompatible with alkalin substances, the pH over 5.0 solutions begin to color. Is inactivated by oxidants.

 

WITHDRAWAL PERIOD

Zero days.

 

STORAGE

Store at temperatures below 25 ° C. Protect from light. Store in original container, tightly closed.

 

PRESENTATION

Bottles containing 20 ml solution for injection.

 

MANUFACTURER: SC PASTEUR – FILIALA FILIPESTI

PRODUCTS FROM THE CATEGORY: Vitamins for horses