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PROLIZ

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proliz-10ml
  • Active Substances: Isopropyl Ester of (±) cloprostenol
  • Solution for the prevention and treatment of breeding disorders and diseases and ih biotechnology of reproduction
  • Target species: horses, cattle, goats, pigs
  • Administration: Intramuscularly
  • Packing: 2 ml, 10 ml

 

COMPOZITION

1 ml contains:

Isopropyl ester of cloprostenol(±)………. 0.2 mg

Excipients:

Benzyl alcohol……………………………………………… 9 mg

Edetate disodium, Disodium phosphate, Monosodium phosphate, Polysorbate 80, Sodium chloride, Water for injections.

 

PHARMACOTHERAPEUTIC ACTION

Isopropyl ester of cloprostenol, a synthetic structural analogue of natural prostaglandin F2α, due to vasoconstriction in the ovary, has a very strong luteolitic effect, producing morphological and functional regression of the corpus luteum followed by estrus and ovulation recurrence. Has ocitocic effect due to stimulation of myometrium contraction.

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TARGET SPECIES

Horses, cattle, goats, swine.

 

INDICATIONS

I. PREVENTION AND TREATMENT OF REPRODUCTIVE DISORDERS AND DISEASES

Cows and heifers – in anestrus (heat quiet), persistent corpus luteum (CGP), ovarian cysts, and dystocia placental retention, chronic endometritis, pyometra, eliminating mumifiat fetus, abortion (on unwanted gestation), induction of parturition, synchronization of heat period;

In anestrus after CGP diagnosis- administration is done in two ways:

  • inoculation followed by artificial insemination (AI) and natural service (MN) the occurrence of oestrus, if it does occur, is the second inoculation at intervals of 11 days and at 72 to 96 hours after this, artificial insemination or natural service, double blind;
  • without estrus detection – take two successive inoculations at intervals of 11 days and at 72 to 96 hours, artificial insemination or natural service double and blind;

In C.G.P. after a single inoculation estrus is shown and is artificial insemination or natural service administered.

In lutein-walled ovarian cyst shall be done in a single shot, and in those with thin walls follicular cyst it is necessary to cause preliminary luteinization _ with chorionic gonadotropin gonadoreline and after 10 to 17 days to inoculate the product.

In chronic endometritis and pyometra, are practiced 2 versions:

  • inoculation with PROLIZ, repeated at 11 days, then artificial insemination _ natural service inoculation.;
  • associating with an estrogen:

- Day 0 – estrogen, 4-day or 5-day – PROLIZ, with a 15-day _ or the 16th repetition, followed at 72 and 96 hours of artificial insemination _ natural service inoculation.

For stopping unwanted pregnancy, administration shall be made from the 7th until the 150th day.

At mares – on persistent corpus luteum (CGP) and anoestrus after calving (AF) – inoculation is made between the 4th and 13th day of the cycle to induce oestrus.

 

II. IN BIOTECHNOLOGY OF REPRODUCTION

Cows and heifers – for heat synchronization is administered in 2 situations:

- When It is known the oestrous cycle – inoculation shall be made between the 5th-day and 16th

- when is not known the oestrous cycle – take two inoculations at intervals of 11 days and in 72 and 96 hours after the second administration shall be made an artificial insemination (AI) _ natural service (MN) double and blind

Pregnant sows – to induce parturition, for synchronization and clustering births – inoculation shall be made between the 110th and 113th day of gestation, required 48 hours before presumptive date of parturition;

In goats – to synchronize heats and possible counter-season schedule births – take two inoculations at intervals of 12 to 14 days.

To prevent placental retention, the product is administered every 60-90 min. from birth.

 

DOSAGE, ROUTE AND METHOD OF ADMINISTRATION

Product should be administered only intramuscularly, both for prevention of reproductive disorders (CGP, ovarian cysts, and dystocia placental retention, chronic endometritis, pyometra) and in biotechnology reproduction (or heat synchronization induced parturition), the following doses:

In cows – 2 ml product / animal (0.400 mg active ingredient);

At mare and sow – 1 ml product / animal (0.200 mg active ingredient);

In goats – 0.5 ml product / animal (0.100 mg active ingredient).

To prevent disturbance of breeding, inoculation is repeated at intervals of 11-14 days, the biotechnology breeding are commonly used single.

 

CONTRAINDICATIONS, PRECAUTIONS AND ADVERSE REACTIONS

Do not use in pregnant females (except for special cases). Do not use in human therapy. PROLIZ injection solution may be absorbed through the skin and may cause bronchospasm or miscarriage. At mare and sow – some signs of restlessness may occur, which disappear after 1 hour. Do not use during pregnancy in animals unless abortion is desired or parturition. Can be used during lactation. Do not associate with gestagenic hormones (progesterone).

Do not administer the medication treatment with non-steroidal anti-inflammatory because it may decrease or nullify the effect of cloprostenol. Concomitant administration with oxytocin potentiate the effect in the uterus. Exceeding the specified dose produces restlessness; combination of the product with gestagenic hormone enhances this state, while reducing the effect of the basic product.

 

WITHDRAWAL PERIOD

Meat and offal: zero days.

Milk: Zero days.

 

STORAGE

Store in a refrigerator at (2 ° C – 8 ° C). Protect from light. Protect from freezing.

 

PRESENTATION

Colorless glass vial with 2 ml solution for injection, amber glass bottles with 10 ml, fitted with rubber stoppers and metal capsule.

 

MANUFACTURER: SC PASTEUR – FILIALA FILIPESTI

PRODUCTS FROM THE CATEGORY: Varia