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PENSTREP

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penstrep-100ml
  • Active substances: Benzylpenicillin procaine, sulphate dihydrostreptomycin
  • Suspension for the treatment of the infections produced by bacteria sensitive to the action of benzylpenicillin procaine and dihydrostreptomycin
  • Target species: bovines, ovine, swine, dogs and cats
  • Administration: intramuscular
  • Packaging: 50 ml, 100 ml, 250 ml

 

COMPOSITION

1 ml contains:

Benzylpenicillin procaine…………..……….. 200 000 UI

Sulphate Dihydrostreptomycin ………………………..200 mg

Excipients: methyl p hydroxybenzoate ……………… 1,8 mg

propyl p hydroxybenzoate ……………………………… 0,2 mg

Excipients: Sodic carboximetilcelulose, Polysorbate 80, Purified water for the injectable solutions.

 

PHARMACO-THERAPEUTICAL ACTION

The two components of PENSTREP-ului synergically act. Procain benzilpenicilina is an antibiotic of the group of penicillins with bactericide action over the Gram-positive bacteria (Bacillus anthracis, Clostridium spp., Corynebacterium spp., Fusobacterium spp., Erysyopelothrix rhusiopathiae, Pasteurela spp., Haemophilus spp. and Brucella spp.).Dihydrostreptomycin is an antibiotic of the group of aminoglycosides with a bacteriostatic and bactericide action, both over the Gram-positive and the Gram-negative bacteria.

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TARGET SPECIES

Bovine, ovine, swine, dogs and cats.

 

INDICATIONS

Bovine, ovine: leptospirose, colibacillose, salmonellose, pasteurellose, infectious entherites, uro-gential and respiratory infections, salmonelic abortion at the sheeps.

Swine: leptospirose, colibacillose, salmonellose, pasteurellose, infectious entherites, uro-gential and respiratory infections, rubella.

Dogs, cats: bacterial infections secondary to the viral diseases, uro-genital and respiratory infections, infectious entherites, streptococci, staphylococci.

 

POSOLOGY, ADMINISTRATION WAY AND MODE

The product is administered intramuscularly, every 24 hours, for 3-5 days at the following doses:

Cattle: 5 ml / 100 kg l.w. (respectively 10.000 I.U. procaine benzylpenicillin and 10 mg dihydrostreptomycin / kg l.w.).

Sheep, swine: 1 ml / 20 kg l.w. (respectively 10.000 I.U. procaine benzylpenicillin and 10 mg dihydrostreptomycin / kg l.w.).

Dogs, cats: 1 ml / 10 kg l.w. (respectively 20,000 I.U. procaine benzylpenicillin and 20 mg dihydrostreptomycin / kg l.w.).

If the animals do not show an improvement of the health state, consult the veterinarian, for the reevaluation of the diagnosis.

 

CONTRAINDICATIONS, CAUTIONS AND ADVERSE REACTIONS

Not to be intra-venously administered. Not to be administered for the penicillin sensitive animals or with serious cardiac or renal disorders. The penicillines are among the safest antibiotics, taking into account the toxicity over the organs. On the Penicillin sensitive animals, there may be present the allergic or anaphylactic reactions.

The toxicity of Dihydrostreptomycine may be expressed by local sensitivizations accompanied by dermatitis, systematic chronic effect, acute systemic effect. It must not be administered for the horses of which meat is designed to the human consumption.

The administration during the pregnancy and lactation of benzylpenicillin procaine and dihydrostreptomycine doesn’t lead to teratogenic and embrion effects. However, the administration will be carefully made during these periods.

In the case of an extended administration, irreversible disorders of the balance sense may occur. The aminoglicozidic antibiotics produce a pulse decrease on the dogs under anesthesia.

The general anesthesics of the d-tubocurarine type may increase the neuro-muscular blocking effect of Streptomicine.

The extended administration of high doses may lead to the hearing loss, vestibular toxicity and nephro-toxic signs. Avoid the administration of the medicine concomitantly with other antibiotics.

 

WITHDRAWL TIME

Meat and organs: bovine, ovine, horses, swine- 28 days

Milk: bovine, ovine- 7 days

 

MAINTENANCE CONDITIONS

To be kept at the refrigerator at 2 – 8°C. To be protected against frost. To be protected against light. Store in original container.

 

EXPOSURE MODE

Glass bottles of 50 ml, 100 ml, 250 ml.

 

MANUFACTURER: S.C. PASTEUR – FILIALA FILIPESTI

PRODUCTS FROM THE CATEGORY: Antibiotics for horses