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OXITOCIN FP

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oxitocina-50ml
  • Active substances: Oxytocin
  • Solution for injection for the disposal of pathological uterine contents, for the induction of uterine involution, uterine bleeding, uterine prolapse, the induction of calving, for milk ejection in case of agalactia, egg binding
  • Target species: cows, mares, sows, sheep, goats, dogs, cats, chickens, ducks
  • Administration: Intramuscularly, subcutaneous, intramurally, intravenous
  • Packing: 50 ml

 

COMPOZITION

1 ml contains:

Oxytocin………………………………………………………. 10 IU

excipients:

Clorobutanol…………………………………………………… 5 mg

Sodium chloride, Glacial acetic acid, Distilled water.

 

PHARMACOTHERAPEUTIC ACTION

Oxytocin is a synthetic compound identical to the natural hormone secreted by the posterior lobe of the hypophysis gland (pituitary gland). Is not administered orally because it is destroyed in the stomach and intestines. Oxytocin causes contraction of uterine smooth muscle and mammary gland involution enhances and stimulates uterine contractions. Does not exercise vasopressors or antidiuretic act.

Uterine muscle response capability to oxytocin depends on the stage of the reproductive cycle. In the early stages of pregnancy, the uterus is less sensitive to oxytocin act, while in the last period of pregnancy significantly increases the sensitivity. This difference is attributed to variable levels of estrogen and progesterone during pregnancy. Lactating cows, which covers the alveolar myoepithelial cells of the mammary glands, shrinks under the influence of oxytocin, leaving milk to pass into the milk ducts pass.

Oxytocin has slight antidiuretic properties and therefore can cause water retention, if administered quickly and in large quantities. Oxytocin is distributed in extracellular fluid, is metabolized in the liver and kidneys and excreted unchanged in small quantities in urine.

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TARGET SPECIES

Cows, mares, sows, sheep, goats, dogs, cats.

INDICATIONS

Oxytocin product is recommended in the following situations:

Cows, mares, sows, sheep, goats, dogs, cats

- Elimination of pathological uterine contents (placental retention, endometritis);

- Induction of uterine involution in animals with hypo – and uterine atonia;

- Uterine bleeding;

- Uterine prolapse (in this case, is injected into the uterine wall thickness, intramiometrial);

- Induction of parturition, but only after the baby has engaged in position.

Cows, sows:

- For milk ejection in case of agalactia (in the first days after birth) and mastitis to clear the fullest quarter ill (injection given 10 minutes before milking quarter);

Pigs, dogs and cats:

- Induction of parturition

Chickens, ducks:

- egg binding.

 

DOSAGE, ROUTE AND METHOD OF ADMINISTRATION

Treatment with oxytocin is injected by Intramuscular injection, subcutaneous or intravenous injection, intramural.

  1. intramuscular administration, subcutaneous and intramural, recommended doses are:

- Cows: 4-6 ml product / animal (40 – to 60 IU / animal);

- Mares: 3 to 4 ml product / animal (30 – to 40 IU / animal);

- Sheep and goats: 1.5 – 2 ml product / animal (15 to 20 IU to / animal);

- Sows: 2 to 4 ml product / animal (by weight) (20-40 IU to / animal);

- Bitches: 0.2 – 1 ml product / animal (depending on size) (2 to 10 IU to / animal);

- Cats: 0.1 to 1 ml product / animal (depending on size) (1-10 IU to / animal);

- Chickens and ducks: 0.2 to 0.5 ml product / animal (2-5 IU to / animal).

  1. The recommended intravenous dose is injected slowly to achieve effect very quickly. The product will be diluted in two volumes physiological serum. Recommended doses are:

- Cows: 2 to 4 ml product / animal (20-40 IU to / animal);

- Mares: 2 to 3 ml product / animal (20 to 30 IU to / animal);

- Sows: 1 to 2 ml product / animal (10 to 20 IU to / animal);

- Sheep and goats: 0.5 to 1 ml product / animal (5 – to 10 IU / animal);

- Bitches: 0.2 – 1 ml product / animal (depending on size) (2 to 10 IU to / animal);

- Cats: 0.1 to 0.5 ml product / animal (depending on size) (1-5 IU to / animal).

If animals do not show an improvement in health your veterinarian should be consulted for diagnosis reassessment.

 

CONTRAINDICATIONS, PRECAUTIONS AND ADVERSE REACTIONS

Do not use in cases of excess volume of the fetus, dystocia through abnormal presentations and positions, uterine torsion, fetal distress, toxicosis. Oxytocin should not be used during early pregnancy, it is triggering premature labor. Not be used if pyometra is present (infection of the uterus) because it can cause uterine rupture. When use oxytocin for induction of parturition, bear in mind that cervical dilation have occurred prior to administration of oxytocin. Otherwise it may cause uterine rupture and fetal death.

In case of overdose is no risk of uterine hypertonia and irreversible fetal distress. Adrenaline reduce the effect of oxytocin on the uterus and mammary gland. Therefore, to avoid frightening the animal, it will be gently handled by master and caretaker.

After i.v injection quick hypotension may occur.

Should not be used concomitantly with sympathomimetics vasoconstrictors or with anesthetics or corticosteroids. The activity of progesterone is diminished oxytocin and cyclopropane anesthesia may increase the risk of arrhythmia. Concomitant sympathomimetics medications may cause hypertension postpartum.

Excessive doses causes myometrial spasm, premature detachment of the placenta, bradycardia, arrhythmias and even fetal death. In case of overdose, treatment is palliative. There is no specific antidote. Oxytocin decomposes under alkaline conditions is incompatible with solutions warfarin plasma and sodium.

 

WITHDRAWAL PERIOD

Not applicable.

 

STORAGE

Store at temperatures below 25 ° C. Protect from direct sunlight and frost. Store in a dry place.

 

PRESENTATION

Amber glass bottles fitted with rubber stoppers and metal capsule 10, 20, 50 ml.

 

MANUFACTURER: SC PASTEUR – FILIALA FILIPESTI

PRODUCTS FROM THE CATEGORY: Varia