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KANAMYCIN FP 25%

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kanamicina-25-100ml
  • Active substances: Kanamycin
  • Injectable solution for the treatment of uro-genital, respiratory, digestive infections, mastitis, salmonellose, mycoplasmose, endo-methrites, septicemias, skin infections, abscesses, flegmons and secondary infections in the case of viral diseases
  • Target species: horses, bovines, ovine, goats, swine, dogs, cats, poultry
  • Administration: subcutaneous or intramuscular
  • Packaging: 100 ml

 

COMPOSITION

1 ml solution contains:

Kanamicina (as sulphate) ………………………………. 250 mg

Excipients:

Methylparahydroxybenzoate…………..………….…2,0 mg

Propylparahydroxybenzoate…………………………….0.2 mg

Sodium citrate, Sodium bi-sulphate, Water for injectable preparations.

 

PHARMACO-THERAPEUTICAL ACTION

Kanamicina is an aminoglicozidic antibiotic obtained by Streptomyces kanamyceticus, bacteriostatic and bactericide, very active both towards the Gram-positive (Corynebacterium spp., Staphylococcus, spp.) and Gram-negative (Aerobacter spp., Enterobacter spp., Escherichia coli, Klebsiella spp., Proteus spp., Salmonella spp.) and acts with a special efficiency especially in the urinary, respiratory, digestive, dermal infections, in the primary, but also in the secondary septicemias, it is efficient towards the microorganisms resistant to other antibiotics and has a bactericide effect to low doses.

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TARGET SPECIES

Horses, bovine, ovine, goats, swine (hens), dogs and cats.

 

INDICATIONS

The treatment of uro-genital, respiratory, digestive infections, mastitis, salmonellose, mycoplasmosis, endo-methrites, septicemias, skin infections, abscesses, flegmons and secondary infections in the case of viral diseases.

Kanamicina is especially administered when the microorganisms acquired resistance to other antibiotics.

 

POSOLOGY, ADMINISTRATION WAY AND MODE

It is administered intramuscular or deep (preferably fractioned at the range of 12 hours) in the following doses, depending on the species of animal and on the weight:

- bovine, horses, swine: 2,4-3 ml/100 kg.g.c./ day (6-7,5 mg s.a./kg g.c./ day)

- calves, colts: 1,5-2,4 ml/50 kg g.c/ day (7,5-12 mg s.a./kg g.c./ day)

- swine, ovine, goats: 2,2-3 ml/kg g.c/ day (11-15 mg s.a./kg.g.c,/ day)

- poultry (hens): 0,1 ml /kg g.c./ day (15 mg.s.a./kg g.c./ day)

- dogs, cats: 0,1 ml product /kg g.c / day (respectively 25 mg s.a /kg g.c)

The administration time is 3-5 days depending on the disease evolution.

If the animals don’t show an improvement of the health state, the veterinary will be consulted, for the re-evaluation of the diagnosis.

 

CONTRAINDICATIONS, CAUTIONS AND ADVERSE REACTIONS

It is not used for the animals with renal insufficiency. It is not administered in case of hyper-sensitivity to the active substance or to any of the Excipients. It is not allowed the use for the layers that produce eggs for the human consumption. It seldom produces pains at the injection place. It is no available specific information regarding the safety and efficacy of use of the product during the pregnancy. It will be avoided the simultaneous administration of other antibiotics (chloramphenicol, tetraciclina) or other aminoglycosides. The simultaneous administration of anse cefalosporines or diuretic increases the oto-toxicity and nephrotoxicity of kanamicina. Kanamicina is inactivated by meticiline. Kanamicina diminishes the absorption of vitamin K, potentiating this way the action of anti-coagulants (e.g., of acetocumarol).

To ensure a correct dosing, the body weight must be established as precise as possible. The overdosing symptoms may include: oto-toxicity, nephro-toxicity and neuromuscular blockage. It forms precipitations with injectable solutions of aminofiline, amfotericina B, novobiocina, carbenicilina, sodic fenobarbital, sodic heparina, sulfizoxazol, sulfametoxipiridazina, oxytetracycline, pentobarbital sodic, vitamina B complex. There have been noticed incompatibilities with the injectable solutions of glucose, oxaciline, sodium hidrogencarbonat, hydrolized of proteins, polimixina B, calcium gluconate, procain chlorhydrate, lidocain chlor-hydrate

 

WITHDRAWL TIME

Meat and organs: Horses, bovine, ovine, goats, swine, poultry- 10 days;

Milk: Bovine, ovine, goats- 36 hours.

 

MAINTENANCE CONDITIONS

To be kept at a lower temperature than 25°C. To be protected against light. To be protected against frost.

 

EXPOSURE MODE

Bottles with 100 ml injectable solution, provided with a rubber stopper and metal cover.

 

MANUFACTURER: S.C. PASTEUR – FILIALA FILIPESTI

PRODUCTS FROM THE CATEGORY: Antibiotics for horses