1 ml injectable solution contains:
Erythromycin (as tiocianate)………………… 50 mg
Benzyl alcohol …………………………….………… 10 mg
Ethylic alcohol, Sodium hydroxide, Propylene-glycol.
Erythromycin is an antibiotic of the group of macrolides. The therapeutic common doses ensure the bacteriostatic effect of erythromycin, and the increased doses grant it a bactericide effect, too. The activity spectrum is very wide and includes: Streptococcus spp., Staphilococcus spp., Bacillus anthracis, Corynebacterium spp., Clostridium spp., Listeria spp., Erysipelothrix rhusiopatiae, Haemophilus spp., Pasteurella spp., Mycoplasma spp., Rickettsia spp., Spirocheta spp. etc.
Erythromycin is bacteriostatic, but it may become bactericide in high concentrations. It penetrates the cell and inhibates the bacterial proteic synthesis. It intervines in the translation process, inhibiting the transport of amino-acids activated (by the aminoacetil-sintetase) at the proteic synthesis place (ribosomes), respectively it competitively coupled with the ARN-messenger receivers (ARM-m), placed on the ribosoms 50-S, prohibiting the creation of polysoms. The bacterial resistance occur by the change of the position of receiver ribosomes and/ or by the increment of the resistance of cellular membrane. The bacterial resistance to erythromycin is fast developed and therefore this antibiotic is only recommended in special cases, respectively in the case of positive antiobiogram or when it is about an infection with penicillin-resistant germs (especially the staphylococcus).
Intramuscularly administered, it is reached the efficient concentration in the blood after about one hour.More info
Swine, ovine, swine,hens and dogs.
For the bovine it is recommended for the treatment of the disorders of respiratory apparatus (pneumonias, bronchitis, pleurisies), digestive apparatus (gastro-enteritis), metritis, placenta retention, panaritium and pododermatitis, abscesses, mastitis, “adjuvant”, for the minimum decrease of the weight losses, produced by the transport stress.
For the swine it is recommended for the gastro-intestinal disorders (gastritis, enteritis), respiratory disorders (pneumonias, bronchitis, rhinitis), mastitis, methritis.
For the ovine it is recommended in the dysentery of the new born lambs, infections of the anterior respiratory ways, mastitis.
For the hens it is recommended in mycoplasmosis, pasteurelosis, rheum, sinusitis, sinovites, streptococcic and staphylococcic infections, decrease of the mortality caused by stress at the hen and turkey hen chickens.
For the dogs it is recommended in the infections produced by erythromycin sensitive germs.
On the big and medium animals, the product is deeply intramuscular administered, and on the poultry, in the deep conjunctive tissue of the neck area, for 3 – 5 consecutive days, depending on the seriousness of the disorder.
The recommended doses are:
Bovine: 5 – 10 ml product/ 50 kg g.c./ day (5 – 10 mg s.a./kg g.c./ day.)
Ovine: 4 ml product/ 50 kg g.c./ day (4 mg s.a./kg g.c./ day.)
Swine: 5 – 10 ml/50 kg g.c./ day (5 – 10 mg s.a./kg g.c./ day.)
On the new-born pigs: 0.5 ml/kg g.c/ day (25 mg/kg g.c./day).
Hens: 0.5 ml product/ kg g.c/ day (25 mg s.a./ kg g.c./day).
Dogs: 1 – 2 ml/10 kg g.c./ at 12 hours ( 5 – 10 mg s.a./kg g.c./ day).
If the animals don’t show an improvement of the health state, the veterinary will be consulted, for the re-evaluation of the diagnosis.
It will be avoided the treatment of allergic animals to erythromycin or to other macrolide antibiotics or of the animals with hepatic disorders. Possible local or systemic allergic reactions. Erythromycin may be administered without any danger for the pregnant cows and pigs, not having bad effects over the development of conception product. It is only used according to the benefit/ risk evaluation, made by the responsible veterinary. Erythromycin is contrary to lincomycin, clindamicina and chloramphenicol by inducing the resistance of staphylococci, each of them being able to provide resistance towards the others. Therefore, they must not be simultaneously administered. It is considered potentially opposed to penicillin, because it fights against its action. Penicillin prohibits the microbial cellular division by inhibiting the synthesis of the cellular walls of bacteria. The metabolism of methylprednisolone may be inhibited by the simultaneous administration with erythromycin.
The probenecide inhibits the tubular re-absorption of erythromycin and extends the maintenance of plasmatic levels. Except for the above mentioned contrary reactions, which occasionally occur, erythromycin is considered a medicine with a low toxicity. Erythromycin is inactivated in alkaline watery or acid solutions.
Meat: Bovine, ovine, swine – 7 days; Hens – 3 days
Milk: Bovine, ovine- 3 days
Do not use on birds that produce eggs for human consumption.
To be kept at a lower temperature than 25°C. To be protected against the direct light and frost.
The product is packed in glass bottles which include 50 ml injectable solution.
PRODUCTS FROM THE CATEGORY: Antibiotics for dogs