1 ml contains:
Sulfadimethoxine ………………………….…….…400 mg
Benzyl alcohol ……………………………………….10 mg
Propylen-glicol, Disodic edethat, Sodium sulfoxilate aldoform, Sodium hydroxyde, Water for the injectable preparations.
Sulfadimethoxine is a chemo-therapeutic substance of the sulphamide group with a quite wide spectrum, of which purely bacterio-static action is due to the competitive antagonism towards the p-aminobenzoic acid, operating as H1. The sulphamides are substances with a bacteriostatic action, their action being proportional to the role of the p-amino-benzoic acid, in the cellular metabolism (either as that, or as precursor of the folic acid). The entheral and parenteral absorption of Sulfadimethoxine is full, it is generally fast absorbed from the intestinal tract, its tissue diffusion being good. Its removal is slow, as that or as metabolic products, through the urine, bladder under acetylate form.
Due to its action range, Enteroxin 40% – injectable solution is efficient for the treatment of infections with Gram-positive germs (streptococci, pneumococci, staphylococci, Clostridium tetani, Bacillus anthracis), with Gram-negative germs (E. coli, Salmonella spp., Pasteurella spp., Haemophyllus influenzae, Klebsiella spp., Enterobacter spp.), certain rikettsi and protozoa (Toxoplasma, Coccidia).More info
Horses, bovine, dogs and cats.
Horses: The treatment of respiratory infections produced by Streptococcus equisi, infections with germs sensitive to Sulfadimethoxine.
Bovine: The treatment of respiratory infections, bacterial pneumonias associated with Pasteurella spp., necrotic podo-dhermites, necrotic laryngite of the calves, determined by Fusobacterium nacrophorum.
Dogs, cats: The treatment of the infections of upper and lower respiratory ways (tonsilites, pharyngites, pneumonias, brochites), of the gastro-intestinal tract (bacterial entherites, bacterial entherites associated to coccidiosis at the dogs), uro-genital (cystitis, nephrites, metritis, pyometritis caused by the infections with streptococci, staphylococcus, Salmonella spp.), the treatment of the infections of soft tissues, abscesses, infections of skin and anal glands.
The product is recommended to be intra-venous (slowly) or deep administered, depending on the body weight, the individual optimum dose for each animal may be established upon the following diagram:
Initial dose: 1,1 ml injectable solution ENTEROXIN 40% to 8 kg body weight (55 mg/kg g.c. /on the first day).
Keeping dose: 0,55 ml injectable solution 40% la 8 kg body weight (27,5 mg/kg g.c./day) at every 24 hours, for 3-5 days, depending on the clinical answer.
It is recommended that the treatment is continued for at least 2 days from the disappearance of symptoms. The treatment initiated with ENTEROXIN 40% injectable solution may be continued with ENTEROXIN 5% oral suspension.
Dogs and cats :
Initial dose: 1,1 ml injectable solution ENTROXIN 40% to 8 kg body weight (55 mg/kg g.c. /on the first day).
Keeping dose: 0,55 ml injectable solution ENTEROXIN 40% to 8 kg body weight (27,5 mg/kg g.c./day) at every 24 hours, for 3-5 days, depending on the clinical answer.
If the animals don’t show an improvement of the health state, the veterinary will be consulted, for the re-evaluation of the diagnosis.
It is not administered for the animals with serious renal and hepatic disorders or discrasis. It is not administered in case of hyper-sensitivity to the active substance or to any of the Excipients. It must not be administered for the horses of which meat is designed to the human consumption.
There may rarely occur gastro-intestinal disorders, lack of appetite, belch, medicine exantem, occasionally abdominal discomfort, case when the administration of the medicine will be immediately stopped.
It will be avoided the administration together with: oral anti-coagulating agents (stressing of the anti-coagulating action); salicylates, phenylbutazone, indometacin; oral anti-diabetics (hypoglycemia danger). It was proven that there is a synergy between trimethoprim and sulfadimethoxine. The overdosing symptoms may include depression or anorexia. Incompatible to the powerfully oxidation agents.
Meat and organs: bovine -7 days;
Milk: 60 hours.
It must not be administered for the horses of which meat is designed to the human consumption.
To be kept at a lower temperature than 25°C. To be protected against light. To be protected against frost. In cold temperature the solution can crystallize but kept in room temperature for a few days or if placed in water bath the crystals dissolve.
Bottles of glass with 100 ml injectable solution, provided with a rubber stopper and aluminium cover.
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