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C.T.P. 12

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CTP-12
  • Active substances: Cloranfenicol, tartrat tilosine, prednisolon, vitamin B12
  • Injectable solution for the treatment of local and systemic infections provoked by the cloramfenicol and tyrosine sensitive germs
  • Target species: dogs, cats
  • Administration: intramuscular
  • Packaging: 100 ml

 

COMPOSITION

1 ml injectable solution contains:

Chloramphenicol .………………………….……….. 200 mg

Tartrat tilosine ………….………………………….. 55 mg

Prednisolon…………………………….……….….. 5 mg

Vitamin B12……………………………………..… 0,1 mg

Excipients: 2-pirolidone, Benzyl Alcohol, Ethyl alcohol, Water for the injectable preparations.

 

PHARMACO-THERAPEUTICAL ACTION

C.T.P. 12 represents a special, synergic medicine combination, which ensures a wide action range over the Gram – positive and Gram negative germs (Streptococcus spp., Staphylococcus spp., Erysipelothrix spp., Nocardia, Clostridium spp., Corinebacterium, Pseudomonas, Pasteurella, Shigella, Chlamydia, Campylobacter spp.), Leptospire, Mycoplasma and Rickettsia The association of a bacteriostatic (chloramphenicol) with a bactericide (tyrosine) grants a high efficiency to the product. The presence of prednisone in the formula, besides the anti-inflammatory substances valence, ensure an appropriate local tolerance, too.

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TARGET SPECIES

Dogs and cats.

 

INDICATIONS

C.T.P. 12 is recommended for the dogs and cats in the treatment of local and systemic infections provoked by the chloramphenicol and tyrosine sensitive germs:

- infections of the digestive apparatus (enteritis, peritonitis, etc.), of the respiratory apparatus (pneumonias, pleurisies), of the genital-urinary apparatus (metritis, nephrites, cystitis)

- infections of the soft skin and tissues

- septicemias, meningitis

- bacterial infections secondary to the viral infections

- bacterial infections resistant to other antibiotics

 

POSOLOGY, ADMINISTRATION WAY AND MODE

The product is deeply intramuscular administered: 0,1 ml/kg body weight/ day (0,5 – 1 ml /10 kg body weight/ day). In special circumstances, on the veterinary’s recommendation, it may be administered at a range of time of 12 hours, too. The period of treatment is 3-5 days.

 

CONTRAINDICATIONS, CAUTIONS AND ADVERSE REACTIONS

It is administered for the animals with hyper-sensitivity to chloramphenicol and tyrosine. It is not administered in the cases of serious hepatic or renal insufficiency, for the new born babies, during the first days of life or for the females during the last side of pregnancy. It is not associated to antibiotics with a high toxicity, sulphamides, anti-diabetics and anti-coagulating agents. C.T.P. 12 must be carefully administered on the young of target species, as well as for the females during the pregnancy period. The treatment with C.T.P. 12 must be based upon the knowledge of the identity and sensitivity of pathogenic agents. C.T.P. 12 is not administered together with other injectable solutions, to avoid the precipitation.

The product is well tolerated in the recommended doses. Skin reactions may seldom occur at the inoculation place, which are remitted within a short period of time. The product is not administered during the last part of pregnancy. Because the chloramphenicol was detected in the milk samples in rate of 50% compared to the serum concentration, the product must be carefully administered during the lactation period.

The following substances may interact with the product: glycosides digitalis, eritromicin, phenobarbital, pentobarbital, primidone, chloramphenicol. It must be administered simultaneously with: phenytoin, primidone, phenobarbital, pentobarbital and cyclophosphamide, penicillin, cephalosporins, lincomycin, glycoside digitalis.

The cats are more sensitive than the dogs, in the case of overdosing, due to the fact that the bisection time of chloramphenicol is higher for the cats. The effects after the overdosing may be: lack of appetite, nausea, diarrhea.

 

WAITING TIME

Not applicable.

 

MAINTENANCE CONDITIONS

To be kept at a lower temperature than 25°C. To be protected against light.

 

EXPOSURE MODE

Bottles of 100 ml solution.

 

MANUFACTURER: S.C. PASTEUR – FILIALA FILIPESTI

PRODUCTS FROM THE CATEGORY: Antibiotics for dogs