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ARTRO – VET B 20

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3D-ARTRO-VET-B-20
  • Active substance: Carprofen, B1 vitamin, B6 vitamin, B12
  • Tablets to control painful inflammatory states and as an analgesic in pain of various etiologies
  • Target Species: Dogs
  • Administration: Oral
  • Packing: 30 tablets/bottle and 2, 10 blisters x10 tablets.

 

COMPOSITION

1 tablet contains:

Carprofen …………………………………….. 20 mg
Vitamin B1 ………………………………….. 10 mg
Vitamin B6 …………………………………. 10 mg
Vitamin B12 …………………………….. 0.020 mg
Excipients q.s. ad ……………………………. 1cpr.
Ingredients: Talc, Magnesium stearate, Stearic acid, Microcrystalline cellulose, Monohydrate lactose, Colloidal silicon dioxide, Sodium glycolate starch.

 

PHARMACOTHERAPEUTIC ACTION

Carprofen is an anti-inflammatory nonsteroidian, propionic acid derivatives group, with intense anti-inflammatory properties, analgesic and antipyretic effects, which also includes ibuprofen, naproxen and ketoprofen. Acts predominantly by inhibiting cyclooxygenases, with consequent reduction of prostaglandin production and a major role in the pathogenesis of inflammation and pain.

Vitamins B1, B6 and B12 introduced in the composition of the product adjust the carbohydrates, fats and proteins metabolism and have a rapid trophic action on the nervous system, gastrointestinal and cardiovascular functions, controlling any undesirable effects due to inflammatory component.

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TARGET SPECIES

Dogs.

 

INDICATIONS

ARTRO-VET B tablets are indicated in dogs:
– The treatment of painful inflammatory condition associated acute or chronic osteoarticular diseases and musculoskeletal (periarthritis, bursitis, tendonitis, sprains, dislocations)
– As an analgesic in pain of various etiologies post-traumatic and post-operative

 

DOSAGE, WAY AND METHOD OF ADMINISTRATION

ARTRO-VET B 20 is administered orally at a dose of 2 tablets for up to 12.5 kg b,w / day (2- 4 mg carprofen / kg b.w. / day) divided in two equal parts in 12 hours
for 7 days. Treatment is continued for another 7 days with 1 tablet administered once.

After 14 days, depending on clinical response and indication of the veterinarian, treatment is reassessed.
Treatment can be started with ARTRO – VET B injection and continued with ARTRO – VET B 20 tablets.

 

CONTRAINDICATIONS, PRECAUTIONS AND SIDE EFFECTS

Do not use in dogs with sensitivity to carprofen; Do not use in pregnant dogs; Must be used with caution in animals with chronic cardiovascular, renal and liver diseases; Do not use in combination with other steroids and non-steroidal anti-inflammatory preparations  due to increased risk of allergies; Do not use in cats. Overall the product is well tolerated and does not cause side effects, while the observed dose. Dermatologic reactions may occur rarely (pruritus, alopecia, rash), gastrointestinal disorders (anorexia, vomiting, diarrhea), liver or kidney. In the event one of the side effects mentioned appeared, the treatment is discontinued, and the animal will be presented to the veterinarian clinic.

Carprofen is not associated with corticosteroids and other non-steroidal anti-inflammatory drugs, because of increasing probability of gastrointestinal adverse effects.

It can interact with sulfonamides, salicylates, sufonylurea antidiabetic agents. Vitamin B1 may enhance the activity of neuromuscular blocking agents. At high doses can cause interference with the metabolism of other B vitamins. Vitamin B6 increases the elimination of nitrofurantoin and may reduce or even annihilate antiparkinsonian action of levodopa because of its dopadecarboxylase activation in peripheral tissues of the brain. Vitamin B12 is poorly absorbed when administered to diabetics who are treated with metformin. Also, colchicine decreases intestinal absorption of cyancobalamin. The combination of anticoagulants and thrombolytic agents with carprofen may aggravate the development of possible ulceration or bleeding lesions of the gastrointestinal mucosa. Carprofen may increase the hypoglycaemic effect of antidiabetics because prostaglandins are directly involved in regulatory mechanisms of glucose metabolism.

Vitamin B1 is degraded by riboflavin and penicillin.

Thiamine can interfere with the absorption and activity of tetracycline.

Vitamin B1 supplements may improve the efficacy of antidepressant medications. Thiamine may inhibit antitumor effect of certain substances used in chemotherapy. Vitamin B1 may help reduce side effects (confusion, muscle weakness, memory impairment) of treatment with scopolamine. Vitamin B6 as well as the other B group vitamins may interfere tetracycline absorption and activity. Some antituberculosis drugs such as cycloserine and isoniazid reduces B6 serum vitamin. Vitamin B6 decreases the effectiveness of hydralazine. Penicillamine, a drug used to treat rheumatoid arthritis causes a decrease in plasma levels of B6 vitamin.
Para-aminosalicylic acid can reduce the absorption of vitamin B12. Vitamin B12 may interfere with the absorption of tetracycline and functional capacity.

Neomycin may reduce intestinal absorption of vitamin B12. Metformin, oral antidiabetic reduces serum levels of folic acid and vitamin B12, but this process can be counteracted by use of oral calcium supplements. Oral Antineoplastics, especially methotrexate, reduce serum levels of vitamin B12.

 

WITHDRAWL TIME

Not applicable.

 

STORAGE

Store at temperatures below 25°C, in their original packaging. Protect from light and moisture.

 

PRESENTATION:

Bottles containing  30 tablets.

Boxes with 2 or 10, blisters of 10 tablets each.

 

MANUFACTURER: SC PASTEUR– FILIPESTI BRANCH

PRODUCTS FROM THE CATEGORY: Anti inflammatory