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ARTRO – VET B 100

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3D-ARTRO-VET-B-100 copy
  • Active substance: Carprofen, vitamin B1, vitamin B6, vitamin B12
  • Tablets to control painful inflammatory states and as an analgesic in pain of various etiologies
  • Target Species: Dogs
  • Administration: Oral
  • Packing: 30tablets/bottle and 2, 10 blisters x10 tablets.

 

COMPOSITION

1 tablet contains:

Carprofen …………………………………… 100 mg
Vitamin B1 …………………………………… 50 mg
Vitamin B6 …………………………………… 50 mg
Vitamin B12 ………………………………… 0.1 mg
Excipients q.s.ad ……………………………… 1cpr
Excipients: Talc, Magnesium stearate, Stearic acid, Microcrystalline cellulose, Monohydrate lactose, Colloidal silicon dioxide, Sodium glycolate starch.

PHARMACOTHERAPEUTIC ACTION

Carprofen is a nonsteroidal anti-inflammatory, propionic acid derivatives group, with intense anti-inflammatory properties, analgesic and antipyretic effects, which also includes ibuprofen, naproxen and ketoprofen. Acts predominantly by inhibiting cyclooxygenases, with consequent reduction of prostaglandin production and a major role in the pathogenesis of inflammation and pain.

Vitamins B1, B6 and B12 introduced in the composition of the product adjusts the carbohydrates, fats and proteins metabolism and have a rapid trophic action on the nervous system, gastrointestinal and cardiovascular functions, controlling any undesirable effects due to anti-inflammatory component.

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TARGET SPECIES

Dogs.

 

INDICATIONS

ARTRO-VET B tablets are indicated in dogs:
– The treatment of painful inflammatory condition associated acute or chronic osteoarticular diseases and musculoskeletal (periarthritis, bursitis, tendonitis, sprains, dislocations)
– As an analgesic in pain of various post-traumatic and post-operative etiologies

 

DOSAGE, WAY AND METHOD OF ADMINISTRATION

Administered orally at a dose of 1 tablet ARTRO-VET B 100/25 – 50 kg b.w / day (2- 4 mg carprofen / kg b.w / day) divided in two equal parts every 12 hours for 7 days.
Treatment is continued for 7 days at a dose of ½ tablet

ARTRO – VET B 100/25 kg b.w / day (2 mg carprofen / kg b.w / day), administered once. After 14 days, depending on clinical response and indication of the veterinarian, treatment is reassessed.
Treatment can be started with ARTRO – VET B injection and continued ARTRO-VET B 100.

 

CONTRAINDICATIONS, PRECAUTIONS AND SIDE EFFECTS

Do not use in dogs with sensitivity to carprofen; Do not use in pregnant dogs; Must be used with caution in animals with chronic cardiovascular, renal and liver disorders. Do not use in combination with other steroids and non-steroidal anti-inflammatory preparations due to increased risk of allergies; Do not use in cats. Overall the product is well tolerated and does not cause side effects, while the observed dose. Dermatologic reactions may occur rarely (pruritus, alopecia, rash), gastrointestinal, liver or kidney disorders (anorexia, vomiting, diarrhea). In the event one of the side effects appears, interrupt the treatment and the animal will be presented for clinical evaluation to the veterinarian.

Carprofen can not be associated with corticosteroids and other non-steroidal antiinflammatory drugs because of increasing probability of gastrointestinal adverse effects. Can interact with sulfonamides, salicylates, sufonylurea antidiabetic agents. Vitamin B1 may enhance the activity of neuromuscular blocking agents. At high doses can cause interference with the metabolism of other B vitamins .Vitamin B6 increases the elimination of nitrofurantoin and may reduce or even annihilate antiparkinsonian action of levodopa because of its dopadecarboxilase activation in peripheral tissues of the brain. Vitamin B12 is poorly absorbed when administered to diabetics who are treated with metformin. Also, colchicine decreases intestinal absorption of cyanocobalamin. The combination of anticoagulants and thrombolytic agents with carprofen may aggravate the development of possible ulceration or bleeding lesions of the gastrointestinal mucosa. Carprofen may increase the hypoglycaemic effect of antidiabetics because prostaglandins are directly involved in regulatory mechanisms of glucose metabolism.

Vitamin B1 is degraded of riboflavin and penicillin.
Thiamine can interfere with the absorption and activity of tetracycline.

Vitamin B1 supplements may improve the efficacy of antidepressant medications. Thiamine may inhibit antitumor effect of certain substances used in chemotherapy. Vitamin B1 may help reduce side effects (confusion, muscle weakness, memory impairment) of treatment with scopolamine. Vitamin B6 as well as the other B group vitamins can interfere tetracycline absorption and activity. Some antituberculosis drugs such as cycloserine and isoniazid reduces serum vitamin B6. Vitamin B6 decreases the effectiveness of hydralazine. Penicillamine, a drug used to treat rheumatoid arthritis causes a decrease in plasma levels of vitamin B6. Para-aminosalicylic acid can reduce the absorption of vitamin B12. Vitamin B12 may interfere with the absorption and functional capacity of tetracycline.

Neomycin may reduce intestinal absorption of vitamin B12

 

WITHDRAWL TIME

Not applicable

 

STORAGE

Store at temperatures below 25°C, in their original packaging. Protect from light and moisture.

 

PRESENTATION

Bottles containing 30 tablets.

Boxes with 2 or 10, blisters of 10 tablets each.

 

MANUFACTURER: SC PASTEUR – FILIALA FILIPESTI

PRODUCTS FROM THE CATEGORY: Anti inflammatory